Pag. 91-93 [prev][index][next]
Tandem transplant in oncohematology
A.M. Carella
Divisione di Ematologia I, Azienda Ospedaliera Universitaria San Martino, Genova
In this last decade, reduced-intensity conditioning (RIC) regimens have been evaluated as a valid alternative to myeloablative regimens. Storb showed in canine models that low doses of TBI provided sufficient immunosuppression to allow hematopoietic donor cell engraftment without the lethal effects of myeloablative preparative regimens. These preliminary observations together with the antineoplastic effects following DLI, led to the diffuse utilization of RIC as a new strategy, mainly for older patients with or without comorbidities. A first review on RIC was published in 2000; recently Giralt has discussed at the last ASH meeting what was learned over the last 10 years in this field.
[>Read full article in PDF]