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How important is to eradicate minimal residual disease in indolent non-Hodgkin’s lymphoma?
A. Rambaldi
Divisione di Ematologia, Ospedali Riuniti Bergamo, Italy
In Follicular non Hodgkin’s Lymphoma (FL-NHL) the molecular diagnosis and monitoring of the chimeric BCL2/IgH gene generated by the t(14;18)is an important tool in the diagnostic work-up at diagnosis and during the clinical follow-up. Although the clinical significance of circulating BCL2/IgH+ cells is still controversial, the persistence of these cells after conventional or high dose chemotherapy programs correlates with a shorter clinical remission.