Pag. 66-67 [prev][index][next]
Gene expression analysis of peripheral T-cell
lymphoma not otherwise specified reveals two distinct subgroups and recurrent pdgfr-alpha deregulation
S.A. Pileri, P.P. Piccaluga, C. Agostinelli, S. Zupo, F. Facchetti, B. Falini, M. Ferrarini
A. Gallamini, D. Novero, M. Paulli, P.L. Zinzani, R. Dalla Favera
Institute of Haematology and Medical Oncology “L. and A. Serà gnoliâ€, Haematology and Haematopathology Units, University of Bologna, Italy; Institute for Cancer Genetics, Columbia University, New York, USA; Division of Medical Oncology C, National Cancer Research Institute, Genoa University, Italy; Department of Pathology, Brescia University, Italy; Institute of Haematology, Perugia University, Italy; Haematology Unit, S. Croce and Carle Hospital, Cuneo, Italy; Department of Biomedical Science and Human Oncology, Pathologic Anatomy Section, Turin University, Italy; Department of Human and Genetic Pathology, Pathologic Anatomy Section, Pavia University, Italy
Peripheral T-cell lymphomas (PTCLs) represent approximately 12% of lymphoid neoplasms.Their incidence varies in different countries and races, being higher in HTLV-1 endemic areas (Asia, Caribbean basin and some parts of the United States).PTCLs are a heterogeneous group of tumours that in the REAL/WHO Classification are roughly subdivided into specified and unspecified (or not otherwise specified, NOS) forms. In particular, the latter – corresponding to about 50% of T-cell lymphomas – cannot be further classified on the basis of morphology, phenotype and conventional molecular studies. Immunohistochemistry does generally show T-cell associated molecule expression, although the phenotypic profile is aberrant in about 80% of cases, CD5 and CD7 being the most frequently defective antigens.
[>Read full article in PDF]