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Development of a predictive model for tumour lysis syndrome in patients with acute myeloid leukemia
P. Montesinos
Valencia, Spain
Tumor lysis syndrome (TLS) can be a life threatening complication during induction chemotherapy in patients with acute myeloid leukemia (AML). TLS is characterized by hyperuricemia, hyperkaliemia, hyperphosphatemia, hypocalcemia and acute renal failure. These abnormalities may occur at presentation of AML due to increased catabolism and turn over of leukemic cells, but more frequently TLS is induced by intensive chemotherapy. Acute urate nephropathy is the main cause of renal failure during TLS, but calcium phosphate precipitation may also contribute to impaired renal function.