Haematologica Reports 2006; 2(issue 3): 6-9[prev][index][next]

Human memory Vγ9Vδ2 T cells require homeostatic cytokines for proliferation
and differentiation
Caccamo N , Meraviglia S , Ferlazzo V , Dieli F , Guggino G , La Mendola C , Salerno A Dipartimento di Biopatologia e Metodologie Biomediche, Palermo, Italy

We have analysed four subsets of human γg9Vδ2 T cells for their capacity to proliferate and differentiate in response to antigen or homeostatic cytokines. Antigen-stimulated cells acquired a central memory (TCM) or effector memory (TEM) phenotype, while IL-15-stimulated cells maintained their phenotype, with the exception of TCM cells, which expressed CD27 and CD45RA in various combinations. These results show that huma nVγ9Vδ2 memory T cells have different proliferation and differentiation potentials and that terminally differentiated (TEMRA) cells result from the TCM subset upon homeostatic proliferation in the absence of antigen.
[>Read full article in PDF]