Haematologica Reports 2006; 2(issue 3): 48-49[prev][index][next]
The effects of combined treatment using paclitaxel and zoledronic acid on tumour
cells and endothelial cells in vitro
Michailidou M, Neville-Webbe HL, Woodward JK , Lefley DV
Brown NJ,1 Coleman RE, Holen I
Clinical Oncology; 1Surgical Oncology, School of Medicine and Biomedical
Sciences, University of Sheffield, Sheffield, UK
Effects in tumour cells
There is increasing use of combined therapies in oncology, but the optimal drug combinations and sequences have in many cases not been determined. The use of bisphosphonates (BPs) together with cytotoxic drugs may be a favourable combination, as BPs like Zometa are usually well tolerated causing few side effects in the patients.1 In this study we have investigating the effects of zoledronic acid (Zometa) in combination with the commonly used cytotoxic drug paclitaxel, in order to determine whether this combination does induce increased levels of apoptotic cell death in breast cancer cells in vitro.2
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