Haematologica Reports 2006; 2(issue 3): 42-44[prev][index][next]
Regulation of integrin function controls angiogenic remodeling
Serini G, Bussolino F
Dipartimento di Science Oncologiche e istituto per la Cura e la Ricerca sul Cancro. Università di Torino, 0060 Candiolo, taly
Vertebrates evolved a cardiovascular system capable of transporting over long distances oxygen and nutrients to the many different tissues that compose their multicellular organism.
Two distinct morphogenetic processes contribute to the development of the embryonic vasculature: vasculogenesis and angiogenesis.1 During vasculogenesis, mesodermal cells differentiate into endothelial cell (EC) precursors (angioblasts), which proliferate and coalesce into a primitive network of homogeneously sized vessels known as primary capillary plexus.
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