Haematologica Reports 2005; 1(issue 9): 15-17
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Tissue factor-PAR2 signaling crosstalk in cancer and
angiogenesis
Ruf W
Department of Immunology, SP258 The Scripps Research Institute
10550 North Torrey Pines Road
La Jolla, CA, USA
Tissue factor (TF) has now well recognized roles as a signaling
receptor involved in the regulation of angiogenesis, tumor growth,
metastasis and inflammation. TF initiates coagulation, leading to
thrombin signaling through G protein coupled, protease activated
receptors (PAR) 1, 3, and 4.1 However, the signaling
activities of the TF-VIIa binary and the TF-VIIa-Xa ternary complex
may occur prior to or even independently of generalized coagulation
activation that lead to fibrin generation, platelet activation and
thrombus formation.2 The TF-VIIa complex activates PAR2
and the product of initiation of coagulation, Xa, while still
assembled in the transient ternary TF-VIIa-Xa complex, signals
through PAR1 or PAR2. [>Read full article in
PDF]
